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Name
ID

Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
MGI:95413

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Decreased circulating IgG level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Leukocytosis

Abnormal granulocyte morphology

Abnormal basophil morphology

Acute lymphoblastic leukemia

Ph-positive acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Acute myeloid leukemia

Chronic myelogenous leukemia

Myeloproliferative disorder

Conjunctivitis

Keratoconjunctivitis sicca

Blepharitis

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Peritoneal abscess

Subacute progressive viral hepatitis

Keratitis

Erythroderma

Asthma

Recurrent infections

Disease(s) Associated with ERCC2

acute lymphoblastic leukemia

acute myeloid leukemia

chronic myeloid leukemia

hepatocellular carcinoma

multiple myeloma

pancreatic cancer

photosensitive trichothiodystrophy 1

xeroderma pigmentosum

xeroderma pigmentosum group D

Mouse Phenotypes		immune system phenotype	enlarged spleen	microgliosis
Availability	Mouse Genotype	immune system phenotype	enlarged spleen	microgliosis
	Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh}	*
	Ercc2^tm3Jhjh/Ercc2^tm3Jhjh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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